Anderlecht 1-3 AEK Athens *
| 28.08.2025 | AEK Athens | 2-0 | Anderlecht | |
| 21.08.2025 | Anderlecht | 1-1 | AEK Athens | |
*Raków 3-1 Arda Kardzhali
| 28.08.2025 | Arda Kardzhali | 1-2 | Raków | |
| 21.08.2025 | Raków | 1-0 | Arda Kardzhali | |
*Celje 3-0 Banik Ostrava
| 28.08.2025 | Banik Ostrava | 0-2 | Celje | |
| 21.08.2025 | Celje | 1-0 | Banik Ostrava | |
*Strasbourg 3-2 Brøndby IF
| 28.08.2025 | Brøndby IF | 2-3 | Strasbourg | |
| 21.08.2025 | Strasbourg | 0-0 | Brøndby IF | |
*Crystal Palace 1-0 Fredrikstad FK
| 28.08.2025 | Fredrikstad FK | 0-0 | Crystal Palace | |
| 21.08.2025 | Crystal Palace | 1-0 | Fredrikstad FK | |
*Jagiellonia 4-1 FC Dinamo City
| 28.08.2025 | FC Dinamo City | 1-1 | Jagiellonia | |
| 21.08.2025 | Jagiellonia | 3-0 | FC Dinamo City | |
*Lausanne-Sport 2-1 Besiktas JK
| 28.08.2025 | Besiktas JK | 0-1 | Lausanne-Sport | |
| 21.08.2025 | Lausanne-Sport | 1-1 | Besiktas JK | |
Hibernian FC 4-5 Legia Warszawa *
| 28.08.2025 | Legia Warszawa | 3-3 AET | Hibernian FC | |
| 21.08.2025 | Hibernian FC | 1-2 | Legia Warszawa | |
Levski Sofia 1-6 AZ Alkmaar *
| 28.08.2025 | AZ Alkmaar | 4-1 | Levski Sofia | |
| 21.08.2025 | Levski Sofia | 0-2 | AZ Alkmaar | |
Neman Grodno 0-5 Rayo Vallecano *
| 28.08.2025 | Rayo Vallecano | 4-0 | Neman Grodno | |
| 21.08.2025 | Neman Grodno | 0-1 | Rayo Vallecano | |
Polissya Zhytomyr 2-6 Fiorentina *
| 28.08.2025 | Fiorentina | 3-2 | Polissya Zhytomyr | |
| 21.08.2025 | Polissya Zhytomyr | 0-3 | Fiorentina | |
Gyori ETO FC 2-3 Rapid Wien *
| 28.08.2025 | Rapid Wien | 2-0 | Gyori ETO FC | |
| 21.08.2025 | Gyori ETO FC | 2-1 | Rapid Wien | |
*Sparta Praha 2-1 Riga FC
| 27.08.2025 | Riga FC | 1-0 | Sparta Praha | |
| 21.08.2025 | Sparta Praha | 2-0 | Riga FC | |
Rosenborg BK 3-5 Mainz 05 *
| 28.08.2025 | Mainz 05 | 4-1 | Rosenborg BK | |
| 21.08.2025 | Rosenborg BK | 2-1 | Mainz 05 | |
*Shakhtar Donetsk 3-2 Servette FC
| 28.08.2025 | Servette FC | 1-2 AET | Shakhtar Donetsk | |
| 21.08.2025 | Shakhtar Donetsk | 1-1 | Servette FC | |
CD Santa Clara 1-2 Shamrock Rovers *
| 28.08.2025 | Shamrock Rovers | 0-0 | CD Santa Clara | |
| 21.08.2025 | CD Santa Clara | 1-2 | Shamrock Rovers | |
Istanbul Basaksehir 2-5 Universitatea Craiova *
| 28.08.2025 | Universitatea Craiova | 3-1 | Istanbul Basaksehir | |
| 21.08.2025 | Istanbul Basaksehir | 1-2 | Universitatea Craiova | |
Wolfsberger AC 2-2 Omonia Nicosia *
| 28.08.2025 | Omonia Nicosia | 1-0/p.5-4 | Wolfsberger AC | |
| 21.08.2025 | Wolfsberger AC | 2-1 | Omonia Nicosia | |