Jocoro FC 2-4 Alianza FC (SLV) *
| 01.12.2021 | Jocoro FC | 2-3 | Alianza FC (SLV) | |
| 05.12.2021 | Alianza FC (SLV) | 1-0 | Jocoro FC | |
*Platense (SLV) 4-3 Luís Ángel Firpo
| 01.12.2021 | Platense (SLV) | 2-2 | Luís Ángel Firpo | |
| 05.12.2021 | Luís Ángel Firpo | 1-2 | Platense (SLV) | |
CD Águila 1-1 Once Deportivo *
| 02.12.2021 | CD Águila | 1-1 | Once Deportivo | |
| 05.12.2021 | Once Deportivo | 0-0/p.4-3 | CD Águila | |
*CD Chalatenango 1-1 CD FAS
| 03.12.2021 | CD Chalatenango | 0-0 | CD FAS | |
| 05.12.2021 | CD FAS | 1-1/p.2-4 | CD Chalatenango | |